TB-500

TB-500

Repairing the Nervous System

Emerging research highlights TB-500's potential in the central nervous system. Studies in rat models of spinal cord injury show promising results, suggesting the peptide's capability to assist in neural repair and regeneration.

TB-500, a synthetic version of the naturally occurring peptide Thymosin Beta 4 (Tβ4), has been found to play a crucial role in cell migration, differentiation, and survival, which are all vital processes for tissue repair. Its mechanism of action in the nervous system is particularly compelling for addressing damage caused by trauma or disease.

Key findings from research in spinal cord injury models indicate several critical neuroprotective and regenerative effects:

• Oligodendrocyte Activation: TB-500 stimulates oligodendrocytes, the glial cells responsible for producing and maintaining the myelin sheath that insulates and protects neurons. This activation is crucial for remyelination, which helps restore rapid signal transmission along damaged nerve fibers.
• Functional Recovery: Rat models treated with TB-500 demonstrated significant improvements in motor function and cognition following spinal cord injury, suggesting a direct positive impact on functional neurological recovery.
• Stem Cell Survival: The peptide enhances the viability and survival of transplanted neural stem cells by reducing oxidative stress and apoptosis (programmed cell death) in the injured microenvironment. This effect is critical for cell replacement therapies.

Therapeutic Potential

These preclinical findings position TB-500 as a key candidate for researching treatments for several severe neurological conditions. Its multifaceted action—promoting cell survival, reducing inflammation, and stimulating repair mechanisms—makes it relevant for a wide range of nervous system disorders:

• Paralysis: By promoting remyelination and functional recovery after spinal cord injury, TB-500 research may lead to therapies aimed at restoring motor and sensory function.
• Stroke: The neuroprotective effects could be beneficial in reducing the extent of damage following an ischemic or hemorrhagic stroke, limiting secondary injury, and promoting recovery in the affected brain regions.
• Neurodegenerative Diseases: Conditions like Alzheimer's and Parkinson's disease, characterized by progressive loss of neurons, may be targets for research into TB-500's ability to enhance stem cell survival and mitigate chronic oxidative stress and inflammation.

Continued research is necessary to translate these findings into safe and effective clinical treatments for humans.

Product Specifications: Research Grade TB-500

The following specifications detail the research-grade TB-500 product available for ongoing scientific study:

Characteristic

Specification

Notes

Purity

High Purity Research Grade

Verified by High-Performance Liquid Chromatography (HPLC) to ensure consistent experimental results.

Formulation

Lyophilized via cryodesiccation

Ensures maximum stability and a long shelf life when stored properly.

Molecular Formula

C212H350N56O78S

Exact molecular structure confirmed for research accuracy.

Storage Condition

Store at -20°C (Prior to reconstitution)

Essential for maintaining peptide integrity.

Source

Synthetic

Produced under strict laboratory conditions.

Handling and Storage Instructions

For optimal research outcomes, strict adherence to handling and storage protocols is required:

Storage (Lyophilized Powder)

• Store the sealed vial containing the lyophilized powder at -20°C (or below) immediately upon receipt.
• Protect the powder from moisture and light. If a deep freezer is unavailable, short-term storage at 2-8°C is acceptable but will reduce the maximum storage life.

Reconstitution

• Allow the vial to reach room temperature before opening.
• Reconstitute the peptide using a sterile, suitable solvent, typically bacteriostatic water or a sterile saline solution, following specific protocol instructions.
• Avoid shaking the vial during reconstitution; gently swirl to dissolve the powder.

Storage (Reconstituted Solution)

• The reconstituted solution must be stored at 2-8°C.
• Avoid repeated freeze-thaw cycles, as this can degrade the peptide structure and compromise research integrity.
• The shelf life of the reconstituted solution is typically limited, and researchers should consult product-specific documentation.

Required Documentation

Researchers utilizing this product should refer to the following documents, which are essential for proper handling, safety, and protocol development:

• Certificate of Analysis (CoA): Confirms the purity, identity, and potency of the specific batch. File
• Safety Data Sheet (SDS): Provides critical information on chemical properties, hazards, and safe handling procedures. File
• Research Protocol Template: A standardized starting document for designing in vitro or in vivo studies. File

Important Notice

TB-500 is sold FOR RESEARCH USE ONLY and is not intended for human consumption or use as a drug, cosmetic, or food additive. All researchers must comply with all applicable institutional, local, and national regulations regarding the handling and use of research-grade materials.